Chromatin untangled: New methods map genomic structure
نویسندگان
چکیده
منابع مشابه
Methods for identifying higher-order chromatin structure.
Eukaryotic genomic DNA is combined with histones, nonhistone proteins, and RNA to form chromatin, which is extensively packaged hierarchically to fit inside a cell's nucleus. The nucleosome-comprising a histone octamer with 147 base pairs of DNA wrapped around it-is the initial level and the repeating unit of chromatin packaging, which electron microscopy first made visible to the human eye as ...
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This two-volume publication contains the proceedings of a NATO Advanced Study Institute, held in April 1978. The material is organized in five sections. In the first section J. Bonner presents a historic review of chromatin research. The following section describes biophysical and chemical methods used in the study of isolated chromatin, such as electron microscopy, circular dichroism, X-ray di...
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Hundreds of different proteins regulate and implement transcription in Saccharomyces. Yet their interrelationships have not been investigated on a comprehensive scale. Here we determined the genome-wide binding locations of 200 transcription-related proteins, under normal and acute heat-shock conditions. This study distinguishes binding between distal versus proximal promoter regions as well as...
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ژورنال
عنوان ژورنال: Science
سال: 2016
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.opms.p1600108